师资队伍
师资队伍

方明亮

教授/博士生导师

Email：mlfang@fudan.edu.cn

研究方向：环境化学与毒理

个人简历

教育简历

  • 2011年8月 - 2015年5月， 杜克大学(Duke University)，环境化学与毒理学，博士

  • 2009年2月 - 2011年2月， 浦项工业大学（POSTECH），环境分析化学，硕士

  • 2002年9月 - 2006年7月， 西安交通大学，环境工程系，学士

工作简历

  • 2022年3月 - 至今，复旦大学，环境科学与工程系，教授

  • 2016年12月 - 2022年3月，新加坡南洋理工大学(Nanyang Technological University)，土木环境工程系，助理教授（终身轨）

  • 2015年5月 - 2016年12月，美国The Scripps Research Institute (TSRI, La Jolla)，代谢组学中心，博士后

  • 2006年7月 - 2009年2月，中国海洋石油天津分公司，EHS工程师

硕士、博士生导师/方向

       课题组主要课题方向为化学品暴露以及环境健康，目前主要项目集中在“暴露组学”方法开发，同时利用高分辨质谱代谢组学等系统生物学方法研究污染物毒性机理和蛋白靶点。目前课题组主要围绕暴露组学和其健康效应等课题方向，有以下几个核心方向以及组内近几年部分相关论文。

       方向一：建立暴露组学数据库和质谱分析方法学平台(Zhao et al, EHP, 2021; Jia et al., ES&T, 2019；Yang et al. ACA, 2019)。

       方向二：研究暴露组概念下，污染物混合物在环境剂量条件下的毒性和健康风险(Liu et al., EHP, 2020; Dong et al. ES&T, 2019; Peng et al. ES&T, 2020; Zhang et al., ES&T, 2020; Fang et al., ES&T, 2015; Fang et al., EHP, 2015; Fang et al., ETC, 2014)。

       方向三：研究暴露组跟细菌组（肠道菌等）之间的相互作用以及对于宿主健康影响（Wang et al., PNAS, 2021; Zhang et al., ES&T 2018；Keerthisinghe et al. EI, 2020）。

       方向四：通过系统生物学方法（代谢组学+化学蛋白组学等）和计算毒理学等手段研究污染物或者药物毒性机理(Beyer* and Fang* et al. Nature Chemical Biology, 2018; Xu et al., ES&T 2020; Xu et al., Anal. Chem. 2021; Xu et al. ES&T 2021)。

学术兼职

  • Environmental Pollution (Elsevier) 副主编，2021-至今

  • Environmental Science: Processes & Impacts (RSC) 编委，2020-至今

  • ACS ES&T Water编委，2021-至今

  • Environment International (Elsevier) 编委，2018-至今

  • Environmental Research (Elsevier) 编委，2019-至今

  • Chemosphere (Elsevier) 编委，2021-至今

  • EXPOSOME (Oxford) 编委，2020-至今

  • Environmental International (Elsevier)客座编辑，2021

  • Journal of Hazardous Material (Elsevier)客座编辑，2020

  • 中国生物物理代谢组学协会委员，2019-至今

  • SSMS（新加坡质谱协会）委员，2018-至今

  • 国际代谢组学协会Metabolomics Society Committee member，2022

  • 新加坡环保部特邀室内空气专家组成员, 2017-至今

  • 新加坡环保部特邀土地质量标准专家组成员，2019-至今

荣誉与奖励

  • 2020年，海外高层次人才引进计划（青年项目）

  • 2017年，Environmental Chemistry and Toxicology 年度10佳论文

  • 2011年，Outstanding publication award, Brain of Korea (BK21)

科学研究

主持和参与的主要项目/课题

  • Investigating opportunities to reduce microfibre pollution from the fashion industry through textile design and manufacturing innovation主持，UNDP-The Future Forum （联合国发展署）

  • Pesticide formulation survey in Singapore主持, NEA（新加坡环保署）

  • Indoor Air Pollutant Control Strategy: With Special Focus on Haze Episode主持, BCA（新加坡住建局）

  • Autologous PKD iPSC-derived kidney organoids: a novel platform for personalized drug screening分项目主持, NMRC（新加坡国家医学研究所）

  • Bedside to bench and back again: evaluating Neisseria spp. as novel respiratory pathobionts using systems biology分项目主持, NMRC（新加坡国家医学研究所）

  • Potential Impacts on Indoor Environmental Quality, Human Health, Thermal Comfort, and ACMV Operations主持, JTC （裕廊集团）

  • Assessing The Public Health Risks And Enhancing The Health of Singapore's Built Environment主持, NEA （新加坡环保署）

  • Biodiversity and Bioprospecting of Magnetotactic Bacteria - An Overlooked Biotechnological Resource in the Tropical Marine Environment of Singapore参与, NRF

  • Metabolite directed detoxification主持,MOE Tier 1 （新加坡教育部）

  • Novel methods for assessing nano-microbiome interactions of ingested engineered nanomaterials: Towards safer-by-design, biocompatible nano-materials in food applications from the gut microbial perspective主持, NTU-Harvard （南洋理工-哈佛大学合作项目）

  • The Interaction between Emerging Organic Contaminants and Gut Microbiome: Implication on 'Gut Green Chemistry' and Healthcare主持, MOE AcRF Tier 1, NTU-SUG （新加坡教育部）

  • Long-Term Environmental Behaviour Evaluation for Municipal Solid Waste Thermal Treatment Residues Used in Road Construction参与, NEA （新加坡环保署）

教研成果

获奖：

2020年，School Teaching Excellence Award，Nanyang Technological University

代表性论文：

1. Mengjing Wang, Qianqian Li, Meifang Hou, Louisa LY Chan, Meng Liu, Soo Kai Terd, Ting Dong, Yun Xia*, Sanjay H Chotirmalld, Mingliang Fang*. Inactivation of common airborne antigens by perfluoroalkyl chemicals modulates early-life allergic asthma. Proceedings of the National Academy of Sciences of the United States of America. 2021

2. Beyer, B. A.#, Fang, M.# （Equal Contribution）, Sadrian, B., Montenegro-Burke, J. R., Plaisted, W. C., Kok, B. P., ... & Lairson, L. L*. (2018). Metabolomics-based discovery of a metabolite that enhances oligodendrocyte maturation. Nature Chemical Biology,  14(1), 22-28. https://doi.org/10.1038/nchembio.2517

3. M Fang, L Hu, D Chen, Y Guo, J Liu, C Lan, J Gong, B Wang. “Exposome” in Human Health: Utopia or Wonderland? The Innovation, 100172, 2021

4. Fanrong Zhao, Li Li, Yue Chen, Yichao Huang, Tharushi Prabha Keerthisinghe, Agnes Chow, Ting Dong, Shenglan Jia, Shipei Xing, Benedikt Warth, Tao Huan and Mingliang Fang*. Risk-based Chemical Ranking and Generating a Prioritized Human Exposome Database. Environmental Health Perspective. 2021.

5. Liu, M., Jia, S., Dong, T., Zhao, F., Xu, T., Yang, Q., ... & Fang, M*. (2020). Metabolomic and Transcriptomic Analysis of MCF-7 Cells Exposed to 23 Chemicals at Human-Relevant Levels: Estimation of Individual Chemical Contribution to Effects. Environmental Health Perspectives  https://doi.org/10.1289/EHP6641

6. Fang, M., Webster, T. F., Ferguson, P. L., & Stapleton, H. M*. (2015). Characterizing the peroxisome proliferator-activated receptor (PPARγ) ligand binding potential of several major flame retardants, their metabolites, and chemical mixtures in house dust. Environmental Health Perspectives,  123(2), 166-172. https://doi.org/10.1289/ehp.1408522

7. Pillai, H. K., Fang, M., Beglov, D., Kozakov, D., Vajda, S., Stapleton, H. M., ... & Schlezinger, J. J*. (2014). Ligand Binding and Activation of PPAR γ by Firemaster® 550: Effects on Adipogenesis and Osteogenesis in Vitro. Environmental Health Perspectives,  122(11), 1225-1232. https://doi.org/10.1289/ehp.1408111 

8. Hoffman, K.#, Fang, M.# （Equal Contribution）, Horman, B., Patisaul, H. B., Garantziotis, S., Birnbaum, L. S., & Stapleton, H. M. *(2014). Urinary tetrabromobenzoic acid (TBBA) as a biomarker of exposure to the flame retardant mixture Firemaster® 550. Environmental Health Perspectives,  122(9), 963-969. https://doi.org/10.1289/ehp.1308028

9. Liu, Min; Jiang, Jie; Jie, Zheng; Huan, Tao; Gao, Bei ; Fei, Xunchang; Wang, Yulan; Fang, Mingliang*. RTP: One Effective Platform to Probe Reactive Compound Transformation Products and Its Applications for a Reactive Plasticizer BADGE. Environmental Science & Technology. 2021. 

10. Xu, Tengfei; Chen, Liyan; Lim, Yan Ting; Zhao, Haoduo; Chen, Hongjin; Chen, Mingwei; Huan, Tao; Huang, Yichao; Sobota, Radoslaw ; Fang, Mingliang*. (2021). Systems Biology-Guided Chemical Proteomics to Discover Protein Targets of Monoethylhexyl Phthalate in Regulating Cell Cycle. Environmental Science & Technology. 2021, 55, 3, 1842–1851.  

11. Xu, T., Lim, Y. T., Chen, L., Zhao, H., Low, J. H., Xia, Y., ... & Fang, M*. (2020). A Novel Mechanism of Monoethylhexyl Phthalate in Lipid Accumulation via Inhibiting Fatty Acid Beta-Oxidation on Hepatic Cells. Environmental Science & Technology. https://doi.org/10.1021/acs.est.0c01073

12. Zhang, Y., Liu, M., Peng, B., Jia, S., Koh, D., Wang, Y., ... & Fang, M*. (2020). Impact of Mixture Effects between Emerging Organic Contaminants on Cytotoxicity: A Systems Biological Understanding of Synergism between Tris (1, 3-dichloro-2-propyl) phosphate and Triphenyl Phosphate. Environmental Science & Technology,  54(17), 10722-10734. https://doi.org/10.1021/acs.est.0c02188

13. Huang, Y., & Fang, M*. (2020). Nutritional and Environmental Contaminant Exposure: A Tale of Two Co-Existing Factors for Disease Risks. Environmental Science & Technology. https://doi.org/10.1021/acs.est.0c05658

14. M Liu, B Peng, G Su, M Fang*. Reactive Flame Retardants: Are They Safer Replacements? Environmental Science & Technology. 2021. 

15. Setyawati, M. I., Singh, D., Krishnan, S. P., Huang, X., Wang, M., Jia, S., Fang, M., ... & Poh, T. Y. (2020). Occupational Inhalation Exposures to Nanoparticles at Six Singapore Printing Centers. Environmental Science & Technology, 54(4), 2389-2400. https://doi.org/10.1021/acs.est.9b06984 

16. Peng, B., Liu, M., Han, Y., Wanjaya, E. R., & Fang, M*. (2019). Competitive biotransformation among phenolic xenobiotic mixtures: Underestimated risks for toxicity assessment. Environmental Science & Technology, 53(20), 12081-12090. https://doi.org/10.1021/acs.est.9b04968

17. Dong, T.#, Zhang, Y.#, Jia, S., Shang, H., Fang, W., Chen, D., & Fang, M*. (2019). Human indoor exposome of chemicals in dust and risk prioritization using EPA’s ToxCast database. Environmental Science & Technology,  53(12), 7045-7054. https://doi.org/10.1021/acs.est.9b00280

18. Jia, S., Xu, T., Huan, T., Chong, M., Liu, M., Fang, W., & Fang, M*. (2019). Chemical isotope labeling exposome (CIL-EXPOSOME): one high-throughput platform for human urinary global exposome characterization. Environmental Science & Technology,  53(9), 5445-5453. https://doi.org/10.1021/acs.est.9b00285

19. Zhang, Y., Keerthisinghe, T. P., Han, Y., Liu, M., Wanjaya, E. R., & Fang, M*. (2018). “Cocktail” of xenobiotics at human relevant levels reshapes the gut bacterial metabolome in a species-specific manner. Environmental Science & Technology,  52(19), 11402-11410. https://doi.org/10.1021/acs.est.8b02629

20. Fang, M., Webster, T. F., & Stapleton, H. M*. (2015). Effect-Directed Analysis of Human Peroxisome Proliferator-Activated Nuclear Receptors (PPARγ1) Ligands in Indoor Dust. Environmental Science & Technology, 49(16), 10065-10073. https://doi.org/10.1021/acs.est.5b01524

21. Fang, M., Webster, T. F., & Stapleton, H. M*. (2015). Activation of Human Peroxisome Proliferator-Activated Nuclear Receptors (PPARγ1) by Semi-Volatile Compounds (SVOCs) and Chemical Mixtures in Indoor Dust. Environmental Science & Technology,  49(16), 10057-10064. https://doi.org/10.1021/acs.est.5b01523 

22. Fang, M., & Stapleton, H. M.* (2014). Evaluating the bioaccessibility of flame retardants in house dust using an in vitro Tenax bead-assisted sorptive physiologically based method. Environmental Science & Technology,  48(22), 13323-13330. https://doi.org/10.1021/es503918m

23. Fang, M., Webster, T. F., Gooden, D., Cooper, E. M., McClean, M. D., Carignan, C., ... & Stapleton, H. M*. (2013). Investigating a novel flame retardant known as V6: measurements in baby products, house dust, and car dust. Environmental Science & Technology,  47(9), 4449-4454. https://doi.org/10.1021/es400032v

24. Chen, Xing; Zhang, Keda; Yin, Zhihong; Fang, Mingliang; Pu, Weidan; Liu, Zhening; Li, Lei; Sinues, Pablo; Dallmann, Robert; Zhou, Zhen; Li, Xue. Online Real-Time Monitoring of Exhaled Breath Particles Reveals Unnoticed Transport of Non-Volatile Drugs from Blood to Breath. Analytical Chemistry, 2021. 

25. T Xu, H Zhao, M Wang, A Chow, M Fang*. Metabolomics and in-silico docking-directed discovery of small-molecule enzyme targets. Analytical Chemistry. 2021.

26. Xing, S., Hu, Y., Yin, Z., Liu, M., Tang, X., Fang, M., & Huan, T.* (2020). Retrieving and Utilizing Hypothetical Neutral Losses from Tandem Mass Spectra for Spectral Similarity Analysis and Unknown Metabolite Annotation. Analytical Chemistry (Washington),  92(21), 14476-14483. https://doi.org/10.1021/acs.analchem.0c02521 

27. Fang, M., Ivanisevic, J., Benton, H. P., Johnson, C. H., Patti, G. J., Hoang, L. T., ... & Siuzdak, G*. (2015). Thermal degradation of small molecules: a global metabolomic investigation. Analytical Chemistry (Washington),  87(21), 10935-10941. https://doi.org/10.1021/acs.analchem.5b03003

28. Warth, B., Spangler, S., Fang, M., Johnson, C. H., Forsberg, E. M., Granados, A., ... & Montenegro-Burke, J. R. (2017). Exposome-Scale Investigations Guided by Global Metabolomics, Pathway Analysis, and Cognitive Computing. Analytical Chemistry 89(21), 11505–11513. https://doi.org/10.1021/acs.analchem.7b02759

29. Preindl, K., Braun, D., Aichinger, G., Sieri, S., Fang, M., Marko, D., & Warth, B*. (2019). A Generic Liquid Chromatography−Tandem Mass Spectrometry Exposome Method for the Determination of Xenoestrogens in Biological Matrices. Analytical Chemistry (Washington), 91(17), 11334–11342. https://doi.org/10.1021/acs.analchem.9b02446

30. H Zhao, Liu, Min, Y Lv, M Fang*. Dose-response Metabolomics and Pathway Sensitivity to Map Molecular Cartography of Bisphenol A Exposure. Environment International. 2021. 

31. D Wang, H Zhao, XunchangFei, SA Synder, M Fang*, M Liu*. A comprehensive review on the analytical method, occurrence, transformation and toxicity of a reactive pollutant: BADGE. Environment International. 2021.

32. Keerthisinghe, T. P., Wang, M., Zhang, Y., Dong, W., & Fang, M*. (2019). Low-dose tetracycline exposure alters gut bacterial metabolism and host-immune response:“Personalized” effect?. Environment International,  131, 104989. https://doi.org/10.1016/j.envint.2019.104989 

33. Keerthisinghe, T. P.#, Wang, F.#, Wang, M., Yang, Q., Li, J., Yang, J., ... & Fang, M*. (2020). Long-term exposure to TET increases body weight of juvenile zebrafish as indicated in host metabolism and gut microbiome. Environment International,  139, 105705.  https://doi.org/10.1016/j.envint.2020.105705

34. Fang, M., Getzinger, G. J., Cooper, E. M., Clark, B. W., Garner, L. V., Di Giulio, R. T., ... & Stapleton, H. M.* (2014). Effect‐directed analysis of Elizabeth River porewater: Developmental toxicity in zebrafish (Danio rerio). Environmental Toxicology and Chemistry,  33(12), 2767-2774. https://doi.org/10.1002/etc.2738

35. Fang, M.*, Guo, J., Chen, D., Li, A., Hinton, D. E., & Dong, W*. (2016). Halogenated carbazoles induce cardiotoxicity in developing zebrafish (Danio rerio) embryos. Environmental Toxicology and Chemistry,  35(10), 2523-2529. https://doi.org/10.1002/etc.3416. 

36. Yang, J. J., Han, Y., Mah, C. H., Wanjaya, E., Peng, B., Xu, T. F., ... & Fang, M. L*. (2020). Streamlined MRM method transfer between instruments assisted with HRMS matching and retention-time prediction. Analytica Chimica Acta,  1100, 88-96. https://doi.org/10.1016/j.aca.2019.12.002

37. Shenglan Jia, Magdiel Inggrid Setyawati, Min Liu, Tengfei Xu, Joachim Loo, Meilin Yan, Jicheng Gong, Sanjay H Chotirmall, Philip Demokritou, Kee Woei Ng, Mingliang Fang*. Association of Nanoparticle Exposure with Serum Metabolic Disorders of Healthy Adults in Printing Centres. Journal of Hazardous Materials, 128710, 2022

38. B Peng, H Zhao, TP Keerthisinghe, Y Yu, D Chen, Y Huang*, M Fang*. Gut microbial metabolite p-cresol alters biotransformation of bisphenol A: Enzyme competition or gene induction? Journal of Hazardous Materials 426, 2022. 

39. Mengjing Wang, Shenglan Jia, Agnes Chow, Mingliang Fang*. Polycyclic aromatic hydrocarbons (PAHs) in indoor environment are still imposing carcinogenic risk Journal of Hazardous Materials. Journal of Hazardous Material. 2020. 

40. TP Keerthisinghe, Q Yang, A Chow, M Fang*. Feeding State Greatly Modulates the Effect of Xenobiotics on Gut Microbiome Metabolism: A Case Study of Tetracycline. Journal of Hazardous Materials. 2021. doi.org/10.1016/j.jhazmat.2021.125441. 

41. Li, J.#, Dong, T.#, Keerthisinghe, T. P., Chen, H., Li, M., Chu, W., ... & Fang, M*. (2020). Long-term oxytetracycline exposure potentially alters brain thyroid hormone and serotonin homeostasis in zebrafish. Journal of Hazardous Materials, 123061. https://doi.org/10.1016/j.jhazmat.2020.123061

42. Huan, T., Forsberg, E. M., Rinehart, D., Johnson, C. H., Ivanisevic, J., Benton, H. P., Fang, M., ... & Thorgersen, M. P. (2017). Systems biology guided by XCMS Online metabolomics. Nature Methods,  14(5), 461-462. https://doi.org/10.1038/nmeth.4260

43. Guang-Lei Ma, Hartono Candra, Li Mei Pang, Juan Xiong, Yichen Ding, Hoa Thi Tran, Zhen Jie Low, Hong Ye, Min Liu, Jie Zheng, Mingliang Fang, Bin Cao, Zhao-Xun Liang*. Biosynthesis of Tasikamides via Pathway Coupling and Diazonium-Mediated Hydrazone Formation. Journal of the American Chemical Society. 2022.

44. GL Ma, HT Tran, ZJ Low, H Candra, LM Pang, QW Cheang, M Fang and ZX Liang*. Pathway Retrofitting Yields Insights into the Biosynthesis of Anthraquinone-Fused Enediynes. Journal of the American Chemical Society. 2021. 

45. Xunchang Fei, Mingliang Fang. Climate change affects land-disposed waste. Nature Climate Change, 2021.

46. Low, J. H., Li, P., Chew, E. G. Y., Zhou, B., Suzuki, K., Zhang, T., Fang, M. et.al (2019). Generation of human PSC-derived kidney organoids with patterned nephron segments and a de novo vascular network. Cell Stem Cell,  25(3), 373-387. https://doi.org/10.1016/j.stem.2019.06.009

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